Skip Ribbon Commands
Skip to main content
Dr. Muhammad Arfan
Associate Professor
Department of Chemistry

SNS
National University of Sciences and Technology (NUST)
School of Natural Sciences, H-12, Islamabad
Tel : +92-51-90855598

Specialization
β-Peptides Synthesis, Organic Synthesis, Natural Product Isolation and Synthesis

Education
Ph.D Chemistry(QAU, Islamabad, Pakistan )

Education:
 
1. Ph. D. Organic Chemistry:Department of Chemistry, Quaid-i-Azam University, Islamabad.
2. Foreign Research Stay:Department of Organic and Bimolecular Chemistry,University of Gottingen, Germany.
3. M. Phil. Organic Chemistry: Department of Chemistry, Quaid-i-Azam University Islamabad.
 
Honour and Awards:
 
1.   Best Researcher Award of 2006 (Organic Section). Chemistry Department Quaid- e- Azam University Islamabad, Pakistan.
2.   HEC fellowship for Gottingen University Germany (25-02-2007 to 25-12-2007) under International Research Support Initiative Program 2006.
3.   Best Researcher Award of year 2007 (Organic Section). Chemistry Department Quaid-I-Azam University Islamabad, Pakistan.
4.   Research Productive Allowance 2007 (G category) PCST (Pakistan Council for Science and Technology).
5.   Best Publication Award of year 2008(Organic Section). Chemistry Department Quaid-e-Azam University Islamabad, Pakistan.
6.   Research Productive Allowance 2008 (G category) PCST (Pakistan Council for Science and Technology).
7.   Best Poster Award 2009 (Organic Section). Chemistry Department Quaid-I-Azam University Islamabad, Pakistan.
8.   Research Productive Award 2010-11 (F category) PCST (Pakistan Council for Science and Technology).
9.   Research Productive Award 2011-12 (G category) PCST (Pakistan Council for Science and Technology).
10. COMSATS Research Productive Award 2012-13.
 
Membership:
 
Life Time Member of Chemical Society of Pakistan
 
Positions Held:
 
  1. 01-1-2003 to 09-09-2003: Lecture, F. G. Quaid-i-Azam College Chaklala-III Rawalpindi.
  2. 29.07.2009- 25-08-2014: Assistant Professor Department of Chemistry COMSATS Institute of Information Technology Abbottabad Pakistan.
  3. 26.08.2014-To-date: Assistant Professor, Department of Chemistry School of Natural Sciences (SNS), National University of Sciences and Technology (NUST),-12, Islamabad.
Projects:

 
Dr.  Muhammad Arfan awarded research grant (worth Rs. 2.8 Million) from Higher Education Commission (HEC), Govt. of Pakistan, to Synthesis and β-Peptides Analog of Neurotensin NT (8-13)

 
Title of Project:              Synthesis and Biological Screening of β-Peptides Analog of Neurotensin NT (8-13)
Amount:                        2.8 Million
Principal Investigator:     Dr. Muhammad Arfan
                                      Assistant Professor
                                      Department of Chemistry SNS, NUST, H-12 Islamabad

 
​​​

Research Areas:

  1. β-peptides Synthesis
  2. Synthesis of peptide drugs
  3. Reagents in organic synthesis
  4. Develop new methodologies

Research Students:

M.Phil Students

 

  1. Sanaullah Fall 2010: GIS/ Geostatistics Mapping of DDT Contaminated soils of Abandoned DDT Factory area Amangrah (Member of Supervisory Committee).
  2. Amina Ali  Fall 2011: Iodine Catalyzed Esterification of N-protected Amino acids (Co-Supervisor).
  3. Muhammad Yasir Spring 12: Schiff Bases of N-Protected Amino acids (Co-Supervisor).
  4. Ghamama Khatoon Spring 12: Chemicals Transformations by using Iodine as catalyst (Co-Supervisor).
  5. Muhammad Atif Khan Fall 13: Antimicricrobial Screening of the Chemical Constituents, Isolated from Swertia chirata. Co-Supervisor).
  6. Asad Hamad Fall 13: Biological Evaluation of Secondary Metabolites isolated from Aerial Parts of Artemisia vulgaris. Co-Supervisor).
  7. Kashif Bashir Fall 13: Biological Screening of Secondary metabolites  Isolated from Bark of Taxus wallichianan (Co-Supervisor).
  8. Kashif Jadoon Fall 13: Phytochemical Studies of Trillium govanianum(Co-Supervisor)
  9. Kiran Kiran Tauqeer (Fall 15-Present)
  10. Memona Shaheen (Fall 15-Present)
  11. Humaira Afzal (Fall 15-Present)
  12. Amina Tahir (Fall 15-Present)

PhD Students:

  1. Asad Aman Ullah: Fall 2014
Research ​Publications:
 
S/No
​Title
1.​ How to improve antifungal bioactivity: POM and DFT study of some chiral amides derivatives of diacetyl-Ltartaric acid and amines, Yahia N. Mabkhot, Muhammad Arfan, Hsaine Zgou, Zuhal K. Genc, Murat Genc, Abdur Rauf,  Saud Bawazeer, Taibi Ben Hadda, Research on Chemical Intermediates, ISSN 0922-6168, Vol., Published online 20 May, 2016,
​2. Mahrukh Malik, Sher Wali Khan,  Muhammad Arfan, Javid Hussain Zaidi, Asghari Bano, Faizan Ullah,  Biological Evaluation of Chiral Amides Synthesized from Diacetyl-L-tartaric Acid and Aromatic Amines, ASIAN J CHEM. 25(2):745-748; 2013.
​3. Auj e Sana, Sher W. Khan, Nida Ambreen, Muhammad Arfan, Javed H. Zaidi, Khalid M. Khan, Shahnaz Perveen & Ghulam A.Miana Asymmetric Induction via Metalation of Succinic Esters and Amide using S(+) Menthol and R(+) 1-Phenylethylamine as Chiral Auxiliaries Letters   in Org. Chem, 9. 632-638, 2012.
​4.

Muhammad Arfan, Khaled A. Shaabana,, Anja Schüffler  and Hartmut Laatscha, Furanone Derivatives from Terrestrial Streptomyces spp.  Natural Product Communications2012,Vol. 7 No. 9 1199-1202.

​5. ​Muhammad Zareef,Rashid Iqbal, Javid Hussain Zaidi, Muhammad Arfan, Muhammad Ali and Khlaid. A New Method of Reducing 2-Mercapto-Substituted1,3,4-Oxadizoles: Synthesis of Acylhydrazine Derivatives,Letters   in Org. Chem.7. 411-414, 2010.
​6. ​Muhammad Zareef,Rashid Iqbal, Khlaid. M. Khan, Javid H. Zaidi; Zia-Ullah and Muhammad Arfan, Convenient Synthesis ofp-substituted 1-arylsulfonyl-pyrrolidin-2-ones, J. Natural Product Research. 23:5, 485- 488, 2009.
​7. ​Muhammad  Zareef,  Rashid Iqbal &Muhammad Arfan. A Novel Synthesis and Antimicrobial Activityof 1-[(Substitutedphenyl sulfonyl] pyrrolidin-2-ones. J.  Enzyme Inhibition Med. Chem. 2008; 23(1): 82-86.
​8. ​Javid H. Zaidi, Khlaid. M. Khan, Sadullah Mir, Naseem Iqbal Gunjal and M. ArfanIn SituSynthesis of Benzyl Chloromethyl Ether and its Use for the Protection and Deprotection of Bifunctional Hydroxyl Compounds, Letters in Org. Chem2008, 5.125-127
​9. ​Javid Hussain Zaidi, Muhammad Arfan, Jabbar Hussain Shahand Khalid Mohammed Khan: An Improved Method of Synthesis of N-protected L-Amino acids As Their Benzoxymethyl (BOM) Esters. Natural Product Research. 22(1), 2008, 22-25.
​10. ​Muhammad Zareef,Rashid Iqbal,Neira Gamboa de Dominguez, Juan Rodrigues, Javid H. Zaidi, Muhammad Arfan, Najim A. Masoudi, Claudiu T. Supuran* Synthesis, Anti-malarial and Anti-HIV Activities of Novel Chiral and Achiral benzenesulfonamides bearing 1, 3, 4-oxadizole moieties;J. EnzymeInhibitionMed. Chem. June 2007, 22(3), 301-308.
​11. ​Ahmad, H. B, Arfan, M.  Rama, N. H   Malana, M. A .A Convenient   Synthesis of 6, 8-Dimethoxy-3-[(2-(4- methoxy phenyl)ethyl] isocoumarin. Chinese Journal of Chemistry, 2007,25, 102-104.
​12. ​Muhammad Zareef, Rashid Iqbal,Najim A.AL- Masoudi  Javid H. Zaidi, Muhammad Arfan and Sohail A. Shahzad: Synthesis, Anti- HIV and Anti- fungal Activities of Novel Benzenesulfonamides Bearing 2, 5-disubstituted-1,3,4 Oxadiazole Moiety. J. Phosphorus, Sulfur, Silicon & Related Elements,182, (2)February 2007, 281-298.
​13. ​Muhammad Zareef,Rashid Iqbal,Najim A. Al - Masoudi, Javid H. Zaidi, Muhammad Arfan.Microwave Assisted Synthesis and Anti-HIV Activity of Novel benzenesulfonamides Bearing 2,5-disubstituted -1,3,4-oxadiazole moiety. Heteroatom Chemistry 2007,18, (4), 425-431.
​14. ​R. Iqbal, S. Ahmed, J. H. Zaidi, M. Zareef, M. Arfan and S. A. Shahzad: A Convenient Synthesis and Antibacterial Activities of Symmetrical and   Asymmetrical 2, 5-Disubsituted 1, 3, 4-Oxadiazoles.Jour.Chem Soc. Pak.  Vol.28, (2), 165-168 2006.
​15. ​Muhammad Zareef, Alessio Innocenti, Rashid Iqbal, Javid H. Zaidi, Muhammad Arfan, Carbonic Anhydrase Inhibitors. Inhibition ofHuman Tumor-associated Isozymes IX and Cytosolic isozymes I and II with Some 1,3,4-oxadiazole-thiols: J. EnzymeInhibitionMedicinal. Chemistry. August; 200621(4). 351-359.
​16. ​R. Iqbal, M. Zareef , S. Ahmed, J. H. Zaidi, , M. Arfan, M. Shafique and N.A. Al- Masoudi: Synthesis, Anti- microbial and Anti-HIV Activity of Some Novel  Benzenesulfonamides Bearing 2, 5- Disubstituted-1,3,4-Oxadiazole Moiety, J. Chinese. Chem. Soc. 53, (3), 689-696 2006.
​17. ​Javid H. Zaidi, M. Arfan, Khalid M. Khan, Shahnaz Perveen and Nida Ambereen:Reactions of N-Protected Amino Acids with Alkyl chloromethyl ethers and Chloromethyl Sulfide. Letters in Org. Chem.3, 242-243 2006.
​18. ​Z. Shafiq, M. Arfan and Nasim H. Rama: Synthesis of Some New Dihalophenyl-, Dihalobenzyisocoumrins and Their (dl)-3,4-Dihydroderivatives. Turk. J. Chem. 29, 321-325, 2005.
​19. ​Habib-ur- Rehman*, M. Arfan, Atta-ur-Rehman, M..I. Choudhary and A. M. Mailk: Chemical Constituents of Taxus wallichiana Zucc. Jour. Chem.  Soc .Pak .25, 4, 321- 325, 2003.
​20. ​Z. Shafiq, Muhammad Arfan, Naseem H. Rama* and M. Hussain: A Convenient One Step Synthesis of trans- Artemidin, and   Tetrachydro Capillarin. IndianJ.  Chem.42B, 1523-1526 2003.
​21. ​Nasim H. Rama, Aamer Saeed and M. Arfan: An   Efficient Synthesis of 3,5  Dimethoxyhomophthalic  Acid, A Key Intermediate for Synthesis of Natural Isocoumarins J. of Heterocyclic Chem. USA 40,519-522, 2003.
 

 

 
Crystallographic Reports:

S/No ​Title
​1. Muhammad Zareef, Rashid Iqbal, Muhammad Arfan and Masood Pervez, 2-[4-Benzyl-5-(2-furyl)4-H-1,2,4- triazole -3-ylsufanyl]acetamide Acta  Cryst. Section E.(2008)  \E 64, o1259.
​2. Krzysztof Ejsmont, Muhammad Zareef, Muhammad Arfan, Sarfaraz A. Bashir and Jacek Zaleski, N`-( 2-flurobenzoyl) benzohydrazide Acta  Cryst. Section E.(2008)E 64, o1128.
​3. ​Muhammad Zareef, Muhammad Arfan, Rashid Iqbal and Masood Pervez, 4-Ethyl -3-(3-pyridyl)-1H-1, 2, 4-triazole-5(4H)-thione 0.095-hydrate Acta Cryst. Section  E. (2008) E 64, o945.
​4. ​Muhammad Zareef, Rashid Iqbal, Muhammad Arfan and Masood Pervez, Ethyl 2-(5-phenyl-1,3,4-oxadiazole-2-ylsulfanyl) acetate   Acta  Cryst. Section E.(2008)E 64, o736.
​5. ​Muhammad Zareef, Rashid Iqbal, Ghulam Qadeer, Muhammad Arfan and Wai-Yeung Wong, N-(4-Fluorobenzoyl)-3, 4, 5-trimethoxybenzohydrazide Monohydrate Acta Cryst. Section E. (2007) E63, o3052.
​6. ​Rashid Iqbal, Muhammad Zareef, Saeeda Aziz, Ghulam Qadeer and Muhammad Arfan Ethyl 2 -(benzoyloxy)benzoateActa Cryst. Section E. (2007) E 63, o744-o745.
​7. ​M. Zareef, R. Iqbal, G. Qadeer, W.-Y. Wong, H. Akhtarand M. Arfan,Crystal structure of 2-bromobenzoic acid hydrazide, C7H7BrN2OZ. Kristallogr. NCS 221 (2006) 305-306 / DOI 10.1524/ncrs.2006.0085.
​8. ​Muhammad Zareef, Rashid Iqbal, Javid.H. Zaidi, Muhammad Arfan and Masood Pervaz,1- [(4- Methylphenyl)sulfonyl]pyrrolidin-2-one.Acta.Cryst. Section E. (2006)E 62, o2955-o2957.
​9. ​Muhammad Zareef, Rashid Iqbal, Javid.H. Zaidi,Muhammad Arfanand MasoodPervaz; N- Benzoyl-N`-methyl-N` (p-tolylsulfony) hydrazine. Acta.Cryst.Section E.(2006)E62, o3049-03051.
​10. ​Muhammad Zareef, Rashid Iqbal, Ghulam Qadeer Muhammad Arfan and Xiaoming Lu. 3,4,5- Trimethoxy Benzohydrazide hemihydrate. Acta. Cryst. Section E.  (2006)E 62, o3259-03261.
11. ​Muhammad Zareef, Rashid Iqbal, , Javid H. Zaidi, and Muhammad Arfan and Masood Pervaz; 4-Methyl-N-[1-(5-(thioxo-4,5-dihydro-1,3,4-oxadizol-2-yl)propyl]Benzene sulfonamide. Acta.Cryst. Section E.(2006)E 62,o2481-o2483.
​12. ​Muhammad Zareef, Rashid Iqbal, Javid.H. Zaidi, Muhammad Arfan andMasood Pervaz: N-{[-(5-(Benzylsulfanyl)-1,3,4-oxadizol-2-yl]- ethyl}-4 chlorobenzenesulfonamide. Acta.Cryst. Section E.(2006)E 62,o2449-o2451.

 

 

Conference Contributions:

S/No ​Title
​1. 15th Tetrahedron SymposiumChallenges in bioorganic and organic medicinal chemistry24-27 June 2014 | London, UK M. M.Arfan*, J.H. Zaidi, M. Zareef,The Mystery of Guanidino group of Arginine(Title of accepted poster presentation in Symposium).
​2. The 1st Conference on Science Diplomacy and Developments in    Chemistry” 24-26 November, 2012Alexandria University and Bibliotheca Alexandrina Egypt, Muhammad Arfan*, Dr.  Javid H. Zaidi, and M. Zareef, The Mystery of Guanidino group of Arginine(Title of accepted paper for oral presentation in conference).
​3. ​3rd Chemistry Conference 2011, on Recent Trends in Chemistry October 17-19, 2011 Organized by Chemistry Division, PINSTECH in Collaboration with Directorate of   Nuclear Fuel Cycleand National Centre for Physics, Islamabad. Sanaullah, Mohammad Amjad Sabir, Qaisar Mahmood and Muhammad Arfan* The Study of DDT in Contaminated Soil of Abandoned DDT Factory area of Amangarh Khyber Pakhtunkhwa. (Title of paper accepted for   poster).
​4. ​9th International and 21st National Chemistry Conference, March 14-16, 2011, Muhammad Arfan*,  Khaled A. Shaaban,  Javid H. Zaidi, Heidrun Anke  and Hartmut Laatsch, Furanone Derivatives from terrestrial Streptomyces spp.(Title of presented paper in conference).
​5. ​28. Tubinger- Gottinger Gesprache zur chemie von Mikrootganismen, Haus Benediktudhohe, zellingen- Retzbach Germany, on 19-21 September 2007.
​6. ​1. Gottinger Chemie- Forum  Georg- August- Universitat Gottingen 29. Juni 2007. Muhammad Arfan*, Javid H. Zaidi,  Synthesis of β-amino acid as Building Blocks for the Synthesis of Biologically active α- Peptides (Title of presented poster in  Forum).
​7. ​6th   International and 16th National Chemistry Conference, Department of Chemistry Bahauddin Zakariya University, Multan, Pakistan. April 6-8, 2006. M.  Arfan* and Javid H. Zaidi “The Use of Benzoxy methyl (BOM) Group to Protect Hydroxyl group in Bifunctional Compounds and Carboxyl Group in N- protected α- Amino acids” (Title of presented paper in conference).
​8. ​10thInternationalSymposium on Natural Product Chemistry, HEJ Institute of Chemistry Karachi. Jan. 6-9, 2006. “Javid H. Zaidi*, Khalid M. Khan, M. Arfan and Sad-Ullah Use of Benzyl Chloromethyl Ether for the Protection / Deprotection of Bifunctional Hydroxyl Compounds.
​9. ​ 4th   International and 14th National Chemistry Conference, P.C.S.I.R. Laboratories Lahore, May 16-18, 2004, M. Arfan*, Nasim. H. Rama and S. Hameed, “Synthesis  of Dihalophenyl- Dihalobenzyl isocoumarin and their Dihydro Derivatives”(Title of presented paper  in conference).
​10. ​3rd International and 13th National Chemistry Conference, Department of Chemistry and H.E.J. Research Institute of Chemistry Karachi University. Dec. 28- 31, 2002.M. Arfan*, Nasim. H. Rama and S. Hameed; Model Synthesis of Naturally Occurring Agrimonolide(Title of presented paper in conference).
​11. ​10th National Chemistry Conference held in the Department of Chemistry, Quaid-i-Azam University, Islamabad Pakistan on 28-30 Oct. 1999. 

 

​Current Courses:

  1. ​Organic Chemistry CHM 801
  2. General Chemistry CH 103
  3. Reading and Research (Ph.D )

Previous Courses:

  1. Advanced Analytical Techniques
  2. Spectroscopic Techniques
  3. Research Méthodology
  4. Introduction Chemical Sciences
  5. Fundamentals of Enviromental Sciences