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Dr. Aneela Javed
Assistant Professor
Healthcare Biotechnology

ASAB
National University of Sciences and Technology (NUST)
Sector H-12, Islamabad
Tel : +92 9085 6129

Specialization
Molecular Medicine (Virology and Immunology)

Education
Post-Doc (Harvard, USA) (Fulbright Research Scholar)  Post-Doc (DUKE-NUS, Singapore) PhD Molecular Medicine (Georg August, Germany)

Dr. Aneela Javed is working as Assistant professor at ASAB (NUST) since March 2012. She received her Masters and M. Phil degree from the Department of Molecular Biology/Biochemistry, Quaid-e-Azam University Islamabad in 2005 and 2007 respectively. She was awarded Higher Education Commission (HEC) overseas scholarship in 2008 and joined German Primate Center, Georg August University, Germany for her PhD research in Molecular Medicine (virology and Immunology). She was among the first batch of “One-Health Pakistan Fellows” by National Academy of sciences USA. She has also served as Visiting Assistant Professor at DUKE-NUS (Singapore) as part of aforementioned fellowship. Dr Aneela is the recipient of “Fulbright Research Fellowship 2017-18” for her post-doctoral work at Harvard Medical School, USA. She is currently heading the “Molecular Immunology” research group at ASAB, NUST.
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The “Molecular Immunology” group focuses on two major aspects namely viral immunology and cancer immunology as well as intersections of both, all culminating in translational research. The group investigates the host-virus interactions and immunological responses against human viruses such as HIV, HCV and HBV both in vitro and in vivo (clinical samples). Based on these interactions, therapeutic strategies are also being under investigation and few are currently being tested. Recently, the group has started working on research and Diagnostic of emerging zoonotic infections such as CCHFV in Pakistan under the umbrella of One-Health. In cancer immunology, the group is investigating the immune correlates as well as new Nano particle based combinatorial therapies for Glioblastoma Multiform (GBM). These therapies are currently being tested in cell lines and Orthotropic Xenograft mouse model.  

INTERNATIONAL RESEARCH COLLABORATIONS  

1. Division of Infectious Diseases, Harvard Medical School, Cambridge, MA, USA. 
2. Department of Emerging infectious diseases, DUKENUS Medical school, Singapore 
3. Proteomics and Mass Spectrometry Laboratory, Department of Clinical Chemistry, University Medicine Göttingen, Georg-August University, Göttingen,                          Germany 
4. Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, UK 

NATIONAL RESEARCH COLLABORATIONS  

1. National Institute of Health (NIH), Islamabad, Pakistan 
2. Pakistan Agricultural Research Council (PARC)
3. National AIDS control Program (NACP), Islamabad, Pakistan 
4. Institute for Biomedical and Genetic engineering (IBGE, KRL).
5. Shaukat Khanum Memorial Cancer Hospital and Research Center 
6. International Islamic university, Islamabad.
7. Khyber Medical University
8. University of Karachi 

Research Supervision of Student Projects:

                      Supervised/Co-Supervised                                Under Supervision/Co-Supervision 
PhD/MS                               2                                                                         4
MS                                        10                                                                        01
BS                                        08/04

Research Grants: (PI & Co-PI):
As PI:
1.   Molecular Characterization of miRNAs involved in anti HIV activity for its therapeutic implication in vaccine development.
2.  Analysing the natural anti-HIV mechanisms for their therapeutic implications in vaccine development. 
3. Deficiency of Artemis protein leading to increased mutation load of TK6 and p53 activation. (completed)
4.  Molecular Surveillance and Risk Factor Evaluation of Crimean Congo Hemorrhagic Fever (CCHF) virus in Pakistan”. (Completed)
5.  The DNA induced Protection against Chicken Coccidiosis in Pakistan". (Completed)

As Co-PI:

1. Elucidation of the Effects of Amphetamine and Natural psycho-stimulant Compounds in Alzheimer’s Disease. (Completed)
2. Development of new multi-target Inhibitor against Hepatitis Infection based on Barbituric Acid Derivatives. (Completed) 

Honours/Awards and scholarships:


1. Sir J. William Fulbright research scholar Fellowship. United States Department of State Bureau of Educational and Cultural Affairs (June 2017)

2. 2. One-Health Fellowship Award by U.S. National Academy of Sciences (March 2016)

3. International Student One Health Alliance (ISOHA) Continent Representatives for Asia (2019-2020)

4. Best Researcher of the year 2015-2016

5. Research Productivity Award 2017 by Pakistan council of science and Technology.

6. Recipient of “Scholarship award for Doctoral studies in Germany from Higher education commission of Pakistan (HEC) (2008-2012).

7. Roll of Honour in B.Sc from “University of the Punjab” , Pakistan
 

LIST OF PEER REVIEWED PUBLICATIONS:


1. Rational design of HIV vaccines and microbicides: report of the EUROPRISE annual conference 2011. J Transl Med. 2012 Jul 11;10:144. doi: 10.1186/1479-5876-10-144

2. Noncytolytic CD8+ Cell Mediated Antiviral Response Represents a Strong Element in the Immune Response of Simian Immunodeficiency Virus-Infected Long-Term Non-Progressing Rhesus Macaques. PLoS One. 2015 Nov 9;10(11):e0142086. doi: 10.1371/journal.pone.0142086. 

3. Increased BST2 expression during simian immunodeficiency virus infection is not a determinant of disease progression in rhesus monkeys. Retrovirology. 2015 Nov 10;12:92. doi: 10.1186/s12977-015-0219-8.

4. Prevalence of High risk Human Papillomavirus in cervical dysplasia and cancer samples from twin cities in Pakistan. Int J Infect Dis. 2015 May;34:14-9. doi: 10.1016/j.ijid.2015.02.018. Epub 2015 Feb 25.

5. Awareness About Cervical Cancer, Human Papillomavirus And Acceptability Of Its Vaccine Among Female University Students Of Peshawar Pakistan. Asian J Agri Biol, 2015, 3(3): 90-96.

6. Pre-infection transcript levels of FAM26F in peripheral blood mononuclear cells inform about overall plasma viral load in acute and post-acute phase after simian immunodeficiency virus infection. J Gen Virol. 2016 Dec;97(12):3400-3412. doi: 10.1099/jgv.0.000632. Epub 2016 Oct 18. 

7. Can IFNL3 polymorphisms predict response to interferon/ribavirin treatment in hepatitis C patients with genotype 3? J Gen Virol. 2016 Oct;97(10):2592-2598. doi: 10.1099/jgv.0.000572. Epub 2016 Aug 5.

8. Heterogeneous genomic locations within NS3, NS4A and NS4B identified for genotyping and subtyping of Hepatitis C virus: A simple genome analysis approach. Infect Genet Evol. 2016 Oct;44:61-68. doi: 10.1016/j.meegid.2016.06.031. Epub 2016 Jun 16.

9. HIV-1 and hijacking of the host immune system: the current scenario. APMIS. 2016 Oct;124(10):817-31. doi: 10.1111/apm.12579. Epub 2016 Aug 19.

10. Prediction of promiscuous T-cell epitopes in the Zika virus polyprotein: An in silico approach. Asian Pac J Trop Med. 2016 Sep;9(9):844-850. doi: 10.1016/j.apjtm.2016.07.004. Epub 2016 Jul 26.

11. Structural and functional annotation of human FAM26F: A multifaceted protein having a critical role in the immune system.Gene. 2017 Jan 15;597:66-75. doi: 10.1016/j.gene.2016.10.029. Epub 2016 Oct 23.

12. LRIGs: A Prognostically Significant Family with emerging therapeutic competence against cancers.  Curr Cancer Drug Targets. 2017;17(1):3-16.

13. Structural annotation of Beta-1,4-N-acetyl galactosaminyltransferase 1 (B4GALNT1) causing Hereditary Spastic Paraplegia 26. Gene. 2017 Aug 30;626:258-263. doi: 10.1016/j.gene.2017.05.041. Epub 2017 May 20.

14. Revisiting the AIDS Epidemic in Pakistan: Where We Stand and What We Must Aim For. AIDS Res Hum Retroviruses. 2017 Oct;33(10):985-992. doi: 10.1089/AID.2017.0042. Epub 2017 Jul 11.

15. Effect of Metformin on Adult Hippocampal Neurogenesis: Comparison with Donepezil and Links to Cognition. J Mol Neurosci. 2017 May;62(1):88-98. doi: 10.1007/s12031-017-0915-z. Epub 2017 Apr 4.

16. Interleukin-6 Rescues Lymphocyte from Apoptosis and Exhaustion Induced by Chronic Hepatitis C Virus Infection. Viral Immunol. 2018 Nov;31(9):624-631. doi: 10.1089/vim.2018.0045. Epub 2018 Sep 15.

17. Bridging the gap by discerning SNPs in linkage disequilibrium and their role in breast cancer. Gene. 2018 Dec 30;679:44-56. doi: 10.1016/j.gene.2018.06.102. Epub 2018 Aug 15.

18. Synthesis, theoretical, spectroscopic and electrochemical DNA binding investigations of 1, 3, 4-thiadiazole derivatives of ibuprofen and ciprofloxacin: Cancer cell line studies. J Photochem Photobiol B. 2018 Dec;189:104-118. doi: 10.1016/j.jphotobiol.2018.10.006. Epub 2018 Oct 9.

19. Structure elucidation, DNA binding, DFT, molecular docking and cytotoxic activity studies on novel single crystal (E)-1-(2-fluorobenzylidene)thiosemicarbazide Journal of Saudi Chemical Society (2018) 22 , 1003–1013

20. Aroylthiourea derivatives of ciprofloxacin drug as DNA binder: Theoretical, spectroscopic and electrochemical studies along with cytotoxicity assessment. Arch Biochem Biophys. 2019 Apr 2;666:83-98. doi: 10.1016/j.abb.2019.03.021. [Epub ahead of print]

COURSES TAUGHT: 

Under graduate:
1. Immunology
2. Molecular Immunology
3. Clinical Genetics
4. Clinical Immunology
5. Modern Research Techniques
6. Vaccinology

Post graduate and PhD:
1. Gene and Cell technology 
2. Human Health and Disease
3. Membrane Topology and signal transduction 
4. Advances in Immunology

The proposed projects will add a valuable knowledge to HIV/AIDS science and thus a better understanding of antiviral responses. Research outcomes can be translated not only into HIV and other retroviral therapeutics interventions.