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Dr. Maria Shabbir
Assistant Professor
Healthcare Biotechnology

ASAB
National University of Sciences and Technology (NUST)
NUST Campus H-12, Islamabad
Tel : +92-51-9085-6137

Specialization
Cancer Genetics/Cancer Theranostics

Education
PhD, Quaid-i-Azam University/ University of Wisconsin, Madison, USA, Islamabad Post Doctrate, University of Wisconsin, Madison, USA

Cancer research is based on identification of causes and development of strategies for prevention, diagnosis, treatment, and cure of cancer.
Cancer research ranges from epidemiology, identification of biomarkers, improvement in diagnostics, treatment regimes to decrease systemic damage during chemotherapy and targeted drug delivery. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards therapies derived from biotechnology research, such as cancer immunotherapy and gene therapy. Cancer research is done in academia, research institutes, and corporate environments, and is largely government funded.
The major focus of this laboratory is Prostate, Breast and Colon Cancers. Our research pursues three major lines of investigation;
  1. Building an understanding of cancer and identification of new molecular targets for intervention.
  2. Chemoprevention of cancer by natural agents.
  3. Complementary and alternative approaches for the targeted cancer treatment. 
The major focus of this laboratory is Prostate, Breast and Colon Cancers. Our research pursues three major lines of investigation;
a)    Building an understanding of cancer and identification of new molecular targets for intervention.
b)    Chemoprevention of cancer by natural agents.
c)    Complementary and alternative approaches for the targeted cancer treatment. 

Projects & Grants

•    Won FICS – 2017 Best project in Biotechnology (0.1 million)
      Project Title:    Nano Medicine 

•    Startup Grant for Fresh PhD Scholars (0.5 million)
      Grant Title:    Potent anti-proliferative, Proapoptotic activity of Taxifolin against liver cancer cells.

•    NRPU HEC 2018: 3.2 million
      Grant Title:  Genes as Possible biomarker in Breast Cancer

Students Supervision
•    MS Students; Supervised
      Ms Sania Safdar 2018 (Completed)
•    MS Students; Under Supervision
      Ms Sadia Safi
      Ms Asma Aabas
      Ms Attia Gulzar
      Ms Kainat Zahra

BS Students Supervised
      Shahrukh
      Areeba
      Maria Shujah
      Rahmeen


 

PEER-REVIEWED JOURNAL ARTICLES

  1. Shabbir M, Denu RA, Nihal M, Singh CK, Longley BJ, Burkard ME, Ahmad N. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 Mar;16(3):517-527. doi: 10.1158/1541-7786.MCR-17-0197. Epub 2018 Jan 12. (IF: 4.974)
  2. Afsar T, Razak S, Shabbir M, Khan MR. Antioxidant activity of polyphenolic compounds isolated from ethyl-acetate fraction of Acacia hydaspica R. Parker. Chem Cent J. 2018 Jan 25;12(1):5. doi: 10.1186/s13065-018-0373-x. (IF: 2.658)
  3. Afsar T, Razak S, Khan MR, Mawash S, Almajwal, Shabbir M. (2016). Evaluation of antioxidant, anti-hemolytic and anticancer activity of various solvent extracts of Acacia hydaspica R. Parker aerial parts. BMC 16, 258(IF: 2.644)
  4. Shabbir, M. Syed, D. N. Lall, R. K. Khan, M. R. Mukhtar, H. (2015). "Potent Anti-Proliferative, Pro-Apoptotic Activity of the Maytenus royleanus Extract against Prostate Cancer Cells: Evidence in In-Vitro and In-Vivo Models." PLOS ONE 10(3): e0119859. (IF: 2.806)
  5. Syed, D. N. K., M. I. Shabbir, M. Mukhtar, H. (2013). "MicroRNAs in skin response to UV radiation." Curr Drug Targets 14(10): 1128-1134. (IF: 3.344)
  6. Shabbir, M. Khan, M. R. Saeed, N. (2013). "Assessment of phytochemicals, antioxidant, anti-lipid peroxidation and anti-hemolytic activity of extract and various fractions of Maytenus royleanus leaves." BMC Complement Altern Med 13: 143. (IF: 2.644)
  7. Bokhari, J. Khan, M. R. Shabbir, M. Rashid, U. Jan, S. Zai, J. A. (2013). "Evaluation of diverse antioxidant activities of Galium aparine." Spectrochim Acta A Mol Biomol Spectrosc 102: 24-29. (IF: 2.098)
  8. Saeed, N. Khan, M. R. Shabbir, M. (2012). "Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L." BMC Complement Altern Med 212: 221. (IF: 2.644)
  9. Khan, A. R. Khan, R. M. Sahreen, S. Shah, A. N. Khan, M. A. Khan, M. Y. Bokhari, J. Rashid, U. Ahmad, B. Shabbir, M. Saeed, N. Jan, S. Afsar, T. (2012). "Amelioration of kidney function markers by Sonchus asper butanolic extract against KBrO3-induced toxicity in rat." J Med Plants Res 6(7): 1224-1228.
  10. Khan, A. R. Khan, R. M. Sahreen, S. Shah, A. N. Khan, M. A. Khan, M. Y. Bokhari, J. Rashid, U. Ahmad, B. Shabbir, M. Saeed, N. Jan, S. Afsar, T. (2012). "Effect of various fractions of Launaea procumbens on antioxidant enzymes in rats liver: Oxidative stress induced by potassium bromate (KBrO3)." Afr J Pharm Pharmacol 6(8): 512-515.
  11. Khan, A. R. Khan, R. M. Sahreen, S. Shah, A. N. Khan, M. A. Bokhari, J. Rashid, U. Ahmad, B. Shabbir, M. Saeed, N. Jan, S. Afsar, T. (2012). "Protective effect of Launaea procumbens against KBrO3 induced nephrotoxicity in rat." Afr J Pharm Pharmacol 6(5): 317-321.
  12. Khan, A. R. Khan, R. M. Sahreen, S. Shah, A. N. Bokhari, J. Shabbir, M. Rashid, U. Jan, S. (2012). "Protective effects of various fractions of Launaea procumbens on molecular markers in rat kidney." Afr J Pharm Pharmacol 6(3): 157-161.
  13. Khan, A. R. Khan, R. M. Sahreen, S. Shah, A. N. Bokhari, J. Shabbir, M. Rashid, U. Jan, S. (2011). "Potassium bromate induced nephrotoxicity: Protective effect of n-hexane extract of Sonchus asper." J Med Plants Res 5(25): 6017–6023.
  14. Khan, M. R. A., M. Saeed, N.  Shabbir, M. (2011). "Protective potential of methanol extract of Digera muricata on acrylamide induced hepatotoxicity in rats." Afr J Biotech 10(42): 8456-8464.
  15. Khan, A. R. Khan, R. M. Sahreen, S. Shah, A. N. Bokhari, J. Shabbir, M. Rashid, U. Jan, S. (2011). "Protective effects of Launaea procumbens against KBrO3-induced hepatic serum marker enzymes." Afr J Pharm Pharmacol 5(23): 2639-2641.
  16. Khan, M. R. H., J. Khan, A. R. Bokhari, J. Shabbir, M. Rashid, U. (2011). "Prevention of KBrO3-induced cardiotoxicity by Sonchus asper in rat." J Med Plants Res 5(12): 2514-2520.
  17. Khan, M. R. M., A. Khan, G.N. Shabbir, M. Saeed, N. Shah, N.A. Bokhari, J. Rashid, U. (2011). "Protective effects of Digera muricata (L) Mart. Against carbon tetrachloride induced oxidative stress in thyroid of rat." Afr J Biotech 10(76): 17564-17570.
 

PUBLISHED ABSTRACTS

  1. Syed DN, RK Lall, Khan MI, Shabbir M and Mukhtar H. Fisetin inhibits p90RSK/YB-1 signaling and downregulates chemoresistance associated P-glycoprotein in A375 melanoma cells. AACR Annual Meeting, At San Diego. 2013.
  2. Syed DN. Syed, Khan MI, Shabana SM, Sechi M, Shabbir M and Mukhtar H. Fisetin inhibits melanoma progression through disruption of AKT-mediated phosphorylation and activation of YB-1. PASPCR annual meeting 2013, Madison, USA 
  3. Maria Shabbir, Minakshi Nihal, Chandra K. Singh, Jack B. Longley and Nihal Ahmad. Potential Pro-Proliferative Function of Polo-Like Kinase 4 in Human Melanoma. AACR Annual Meeting, New Orleans. 2016.
  4. Maria Shabbir, Minakshi Nihal, Chandra K. Singh, Jack B. Longley and Nihal Ahmad. A pro-proliferative function of centriole duplication regulator, polo-like kinase-4 in human melanoma. SID Annual meeting, Scotts dales, Arizona, 2016.
  5. Chandra K, Maria Shabbir, Minakshi Nihal,. Singh, Jack B. Longley and Nihal Ahmad. Potential Pro-Proliferative Function of Polo-Like Kinase 4 in Human Prostate Cancer. AACR Annual Meeting, New Orleans. 2016.
  6. Chandra K, Maria Shabbir, Minakshi Nihal,. Singh, Jack B. Longley and Nihal Ahmad. Potential Pro-Proliferative Function of Polo-Like Kinase 4 in Human Melanoma. SID Annual meeting, Scotts dales, Arizona. 2016.

​Introduction of new elective course for MS/PhD Health Care Biotechnology
Course:   Metabolomics: Methods & Applications

MS Courses

Cancer Biology
Cancer Genetics

BS Course

Immunopathology & Immunotherapy
Cell Biology
Vaccinology
Animal Physiology

2013- 2013: Research scholar University of Wisconsin –Madison USA (3 months)
Studied prostate cancer signaling after treatment with M. royleanus extract in in-vitro/ in-vivo systems, along with Fisetin, Caffeic acid and Quercetin

2012- 2013: Research scholar, IRSIP Higher Education Commissions’ scholarship (6 months) University of Wisconsin –Madison USA 
Studied prostate cancer signaling after treatment with M. royleanus extract in-vitro/ in-vivo, along with Fisetin, Caffeic acid and Quercetin.

2010-2011: Research Associate     
Quaid -i-Azam University, Islamabad
Pharmacological and Biological activities of medicinal plants in in-vitro/ in-vivo systems.

2010–2011: Internship      
National Control Laboratories for Biologicals, Islamabad, Pakistan.
Screening of Vaccines (potency testing, sterility testing & cytotoxicityscreening.