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Dr. Rumeza Hanif
Assistant Professor
Healthcare Biotechnology

ASAB
National University of Sciences and Technology (NUST)
Atta-ur-Rahman School of Applied Biosciences
Tel : +92 51 9085 6155

Specialization
Cancer Theranostics and Biometal Tranpsort

Education
Post-Doc: LUMS, Pakistan (2012): PhD, Biochemistry (2007-2011) University College London (UCL), UK

Dr. Rumeza joined NUST in October, 2012 as an Assistant Professor. She received her M.Sc. degree in Agricultural Chemistry from Agricultural University Peshawar in 2007. Then she moved to London for her PhD studies in Biochemistry and Molecular Biology after an award of overseas scholarship from Higher Education Commission, Pakistan. The focus of Ph.D. project at University College London (2007-2012) was on understanding the molecular mechanism of regulation of iron transport across placenta.  Currently she is working on various single nucleotide polymorphisms and Estrogen Receptor alpha associated Biological Regulatory Network related to Breast Cancer. Another aspect of her research is the targeted delivery of anti-cancerous drugs using nanoparticles synthesized from probiotics enzymes to reduce systemic damage.

HEC Approved Supervisor: http://www.nust.edu.pk/Admissions/PhD-Program/Pages/List-of-PhD-Supervisor.aspx

Research Grants (PI):
2018: "Gold nanoparticles as a targeted drug delivery vehicle in breast cancer therapy" NRPU-HEC, (PKR 3.2 M)
2013: “Spectrum of beta-thalassemia in Province Punjab and KPK: identification of novel mutations” HEC, (PKR 0.5M)

Present Predoctoral Trainees
    Sundus Naila        2014-present
    ‘Effect of Combinatorial Drug Therapy on the Progression of Breast Cancer’

Past PhD Trainees
    Samra Khalid        2012-2018
‘Identification and Modeling of Regulatory Networks and Development of anti-cancer Drug-conjugated Nanoparticles for Breast cancer Therapy’

Past M.Sc. Trainees   
    Asma Mumtaz      2016-2018
‘Biosynthesis, Characterization and Biological Applications of Gold Nanoparticle’
    Wajeeha Javed      2016-2018
‘Targeting HIF-1α signaling pathway for Cancer Treatment’  
    Syeda Yumna Farukh      2015-2018
‘Isolation, characterization and evaluation of in vitro cellular responses induced by lactic acid bacterial strains’
    KamiliaTasleem        2015-2018
‘Screening, isolation and evaluation of cytotoxic activities of different probiotic strains from rice’
    Fatima Khan        2015-2018
‘Screening, isolation and evaluation of in vitro cellular response induced by different probiotic strains isolated from Rice’
    Ifrah Rafaqat        2015-2018
‘Isolation, characterization and assessment of antibacterial and anti-cancerous activity of probiotic strains isolated from animal sources’
    Arslan Amir        2014-2016
‘Isolation and characterization of Lactobacillus strains and evaluation of their antibacterial and cytotoxic activities’
    Nayyab Khan       2014-2016
‘Isolation and characterization of Bifidobacterium animalis strains and evaluation of their antibacterial and cytotoxic activities’
    Rooma Khan        2013-2015
‘Investigation of mutations in β- thalassaemic patients in the province of Khyber Pakhtunkhuwa’
    Aadil Javed        2013-2015
‘Mycosynthesis, Characterization and Evaluation of Therapeutic Potentials of Silver Nanoparticles’

Past B.Sc. Trainees (Final Year Project)
    Zahra Rafique             2018
    Aysha Bilal                  2018
    Maham Khan              2017
    Zuneira Qureshi         2017   
    Shizza Khan               2017           
    Kandeel Khan             2016
    Maham Shakoor         2016
    Saneea Imran             2016
    Momina Masud          2015
    Arslan Amir               2014
    Zainab Sohail            2014

Honours and Awards:
•    Qualified for the indigenous scholarship (10 % Overseas Scholarship Scheme, Phase II,
Batch-2) for Ph.D. studies at University College London from Higher Education Commission, Pakistan in 2007
•    Awarded Silver medal in M.Sc. (Hons) for obtaining 2nd position from NWFP Agricultural University Peshawar, Pakistan in 2007

•    Awarded Bronze medal in B.Sc. (Hons) for obtaining 3rd position from NWFP Agricultural University Peshawar, Pakistan in 2004
*Corresponding Author
Maqbool SN, Nazeer HS, Rafiq M, Javed A, Hanif R*. Bridging the gap by discerning SNPs in linkage disequilibrium and their role in breast cancer. Gene 2018; 15;679:44-56. https://doi.org/10.1016/j.gene.2018.06.102. (IF 2.4)

Khalid S, Hanif R*, Jabeen I, Muhammad I. Pharmacophore modeling for identification of anti-IGF-1R drugs and in-vitro validation of fulvestrant as a potential inhibitor. Plos ONE 2018; https://doi.org/10.1371/journal.pone.0196312. (IF 2.7)

Khalid S, Hanif R*. Association of rs1801157 single nucleotide polymorphism of CXCL12 gene in breast cancer in Pakistan and in-silico expression analysis of CXCL12–CXCR4 associated biological regulatory network. PeerJ 2017; doi: 10.7717/peerj.3822. (IF 2.1)

Ikram A, Zaheer T, Awan FM, Obaid A, Naz A, Hanif R, Paracha RZ, Ali A, Naveed AK,  Janjua HA. Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches. Scientific Reports 2018; 8:16107 | DOI:10.1038/s41598-018-34254-5.(IF 4.1)

Khalid S, Hanif R*, Tareen SHK, Siddiqa A, Bibi Z, Ahmad J. Formal modeling and analysis of ER-α associated Biological Regulatory Network in breast cancer. PeerJ 2016; 4:e2542 https://doi.org/10.7717/peerj.2542. (IF 2.1)

Khalid M, Khalid N, Ahmed I, Hanif R, Ismail M, Janjua HA. Comparative studies of three novel fresh water microalgae strains for synthesis of silver nanoparticles: Insights of characterization, antibacterial, cytotoxicity and antiviral activities. Journal of Applied Phycology 2016: 29, 4: 1851–1863. (IF 2.4)

Ikram A; Obaid A; Naz A; Awan FM; Hanif R; Paracha RZ; Ali A; Janjua HA. Identification of drug resistance and immune-driven variations in hepatitis C virus (HCV) NS3/4A, NS5A and NS5B regions reveals a new approach toward personalized medicine. Antiviral Research 2016; 137, 112e124. (IF 4.3)

Balesaria S, Salama M, Hanif R, Hundley F, McArdle H, Srai K. Regulation of iron transporters and regulatory proteins in developing wild type (HFE+/+) and knockout (HFE-/-) neonate mice. American Journal of Hematology 2013; 88(5):E199-E200. (IF 3.6)

Balesaria S, Hanif R, Salama M, Raja K, Bayele HK, McArdle H, and Srai SK. Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron. Haematologica. 2012; 97, 661-669. (IF 5.6)

Surjit KS, Chung B, Marks J, Pourvali K, Solanky N, Rapisarda C, Chaton TB, Hanif R, Unwin RJ, Debnam ES, Sharp PA. Erythropoietin regulates intestinal iron absorption in a rat model of chronic renal failure. Kidney International 2010; 78, 660-667. (IF 6)

Iqbal Z, Shah H, Hamid FS, Iqbal M, Hanif R. Minerals soluble in black tea brew and their role in human health. Sar. J. Agri. 2006; 22(3) 529-539.

Hanif R, Iqbal Z, Iqbal M, Hanif S and Rasheed M. Use of Vegetables as Nutritional Food: Role in Human Health. J. Agri. and Biol. Sci. 2006; 1(1) 18-22.

Iqbal M, Iqbal Z, Hanif R, Shah H, Habibullah. Phytic acid and mineral contents of different varieties of corn. Sar. J. Agri. 2005; 21, 751-755.

​Teaching following Undergraduate & Postgraduate courses at NUST since 2012:

1.    Human Health and Disease (PG)
2.    Trends in Cell Biology (PG)
3.    Cell Signalling (UG)
4.    Gene Therapy and Viral Vectors (UG)
5.    Cell Biology (UG)